Stereodivergent Olefination of Enantioenriched Boronic Esters
نویسندگان
چکیده
A stereodivergent coupling reaction between vinyl halides and boronic esters is described. This coupling process proceeds without a transition-metal catalyst, instead proceeding by electrophilic selenation or iodination of a vinyl boronate complex followed by stereospecific syn or anti elimination. Chiral, nonracemic boronic esters could be coupled with complete enantiospecificity. The process enables the highly stereoselective synthesis of either the E or Z alkene from a single isomer of a vinyl coupling partner.
منابع مشابه
50 Years of Zweifel Olefination: A Transition-Metal-Free Coupling
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عنوان ژورنال:
دوره 56 شماره
صفحات -
تاریخ انتشار 2017